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ATCC s pneumoniae atcc 6303
S Pneumoniae Atcc 6303, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 580 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/s+pneumoniae+atcc+6303/Streptococcus+Pneumoniae/pmc12597061__mmc1-105-41-43
Average 96 stars, based on 580 article reviews

s pneumoniae atcc 6303 - by Bioz Stars, 2026-10

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Article Title: Anti-cytokine autoantibodies linked to susceptibility, bacterial load, and outcome in pneumococcal meningitis: prospective cohort studies in CNS infections, Alzheimer's disease, and Parkinson's disease
Article Snippet: Cells were stimulated overnight with cytokine and the next day SEAP production was quantified using the QUANTI-Blue (Invivogen) colorimetric enzyme assay.

Article Title: Bacterial load in cerebrospinal fluid predicts unfavourable outcome in pneumococcal meningitis: a prospective nationwide cohort study.
Article Snippet: External standard curves were created using genomic DNA extracted from S. pneumoniae ATCC 6303.

Article Title: Integrative In Silico and Experimental Characterization of Endolysin LysPALS22: Structural Diversity, Ligand Binding Affinity, and Heterologous Expression
Article Snippet: S. pneumoniae ATCC 6303 , 17.5 , 22 , 17 , 69 , 69 , 0.97 , 97 , 0.77 , 77.

Article Title: Back to Nature: Medicinal Plants as Promising Sources for Antibacterial Drugs in the Post-Antibiotic Era
Article Snippet: Stryphnodendron adstringens /bark , Ethanolic extract , Polyphenols and tannins , - , N. gonorrhoeae ATCC 49226 K. pneumoniae ATCC13693 MRSA (clinical isolate) S. pneumoniae ATCC 6303 , 3.125 mg/mL 12.5 mg/mL 3.125 mg/mL 0.78 mg/mL , [ ] .

Article Title: 3-substituted phenazine derivatives as antimicrobial agents
Article Snippet: Bacterial strains used during these investigations include: S. aureus BAA-1707 (“MRSA-1707”), BAA-44 and UAMS-1, S. epidermidis ATCC 35984, E. faecium ATCC 700221, E. faecalis OG1RF (ATCC 47077), S. pneumoniae ATCC 6303, M. tuberculosis H37Ra (ATCC 25177) and CDC1551.

Bacteria:

Article Title: Asclepain cI, a proteolytic enzyme from Asclepias curassavica L., a south American plant, against Helicobacter pylori .
Article Snippet: Those extracts showed antibacterial activity against Clostridium histolyticum ATCC 6282, an anaerobic gram-positive bacterium that can cause gas gangrene in humans and animals, and against Escherichia coli ATCC 8739, a gram-negative, facultative anaerobe, no sporulation coliform bacterium. .. However, the same extracts did neither inhibit the growth of Bacteroides fragilis ATCC 23745 (an anaerobic gram-negative bacillus) nor in several grampositive bacteria, such as Staphylococcus aureus ATCC 6538, S. epidermidisATCC 12228, S. capitisATCC 35661, S. cohniiATCC 35662, Streptococcus pyogenes ATCC 19615, S. bovis ATCC 49133, S. agalac tiae ATCC 13813, S. pneumoniae ATCC 6303, S. lactis ATCC 7962, Streptococcus sp. ATCC 12388, Bacillus subtilis ATCC 6633, B. megaterium ATCC 89, Corynebacterium diphtheriae ATCC 13812, and C. pseudodiphtheriticum ATCC 10700 (Neto et al., 2002). ..

Article Title: Asclepain cI, a proteolytic enzyme from Asclepias curassavica L., a south American plant, against Helicobacter pylori
Article Snippet: Those extracts showed antibacterial activity against Clostridium histolyticum ATCC 6282, an anaerobic gram-positive bacterium that can cause gas gangrene in humans and animals, and against Escherichia coli ATCC 8739, a gram-negative, facultative anaerobe, no sporulation coliform bacterium. .. However, the same extracts did neither inhibit the growth of Bacteroides fragilis ATCC 23745 (an anaerobic gram-negative bacillus) nor in several gram-positive bacteria, such as Staphylococcus aureus ATCC 6538, S. epidermidis ATCC 12228, S. capitis ATCC 35661, S. cohnii ATCC 35662, Streptococcus pyogenes ATCC 19615, S. bovis ATCC 49133, S. agalac tiae ATCC 13813, S. pneumoniae ATCC 6303, S. lactis ATCC 7962, Streptococcus sp . .. ATCC 12388, Bacillus subtilis ATCC 6633, B. megaterium ATCC 89, Corynebacterium diphtheriae ATCC 13812, and C. pseudodiphtheriticum ATCC 10700 (Neto et al., ).

Centrifugation:

Article Title: Predictive signature of murine and human host response to typical and atypical pneumonia
Article Snippet: .. S. pneumoniae ATCC 6303 (American Type Culture Collection) was grown to mid-logarithmic phase in Todd-Hewitt broth for 6 hours at 37°C and harvested by centrifugation. ..

Image Search Results

a , Schematic of the mouse infection model. Mice were intranasally (i.n.) primed with PBS or influenza A virus (IAV; 10 PFU) and subsequently infected with S. pneumoniae D39L at 7, 14 or 28 d post IAV infection. Bacterial inocula were ∼1 × 10⁸ CFU for pneumococcal infection alone (Spn) and ∼1 × 10⁴ CFU for superinfected (SI) mice. Mice were euthanized 24 h after bacterial challenge. b–d, Lung bacterial burdens in mice infected with S. pneumoniae ( b ) 1 week, ( c ) 2 weeks or ( d ) 4 weeks following IAV infection. Dots indicate individual mice, bars depict geometric means ± geometric standard deviation (s.d.) (n=2-3, one representative of at least two experiments shown). Statistical significance was determined by ordinary one-way ANOVA with Tukey’s multiple-comparisons test. e,f, Principal component analysis (PCA) of S. pneumoniae transcriptomes recovered from Spn and SI mice 24h post inoculation, (e) 1 week and (f) 2 weeks post IAV infection. g, Venn diagram showing S. pneumoniae genes upregulated during SI at week 1 and week 2. h,i , Volcano plots showing differentially expressed S. pneumoniae genes during SI compared with Spn infection 24h post inoculation, (h) 1 week and (i) and 2 weeks post IAV infection. Genes commonly upregulated at both time points are highlighted in blue.

Journal: bioRxiv

Article Title: Early metabolic reprogramming licenses Streptococcus pneumoniae for Influenza-driven superinfection

doi: 10.64898/2026.01.10.698720

Figure Lengend Snippet: a , Schematic of the mouse infection model. Mice were intranasally (i.n.) primed with PBS or influenza A virus (IAV; 10 PFU) and subsequently infected with S. pneumoniae D39L at 7, 14 or 28 d post IAV infection. Bacterial inocula were ∼1 × 10⁸ CFU for pneumococcal infection alone (Spn) and ∼1 × 10⁴ CFU for superinfected (SI) mice. Mice were euthanized 24 h after bacterial challenge. b–d, Lung bacterial burdens in mice infected with S. pneumoniae ( b ) 1 week, ( c ) 2 weeks or ( d ) 4 weeks following IAV infection. Dots indicate individual mice, bars depict geometric means ± geometric standard deviation (s.d.) (n=2-3, one representative of at least two experiments shown). Statistical significance was determined by ordinary one-way ANOVA with Tukey’s multiple-comparisons test. e,f, Principal component analysis (PCA) of S. pneumoniae transcriptomes recovered from Spn and SI mice 24h post inoculation, (e) 1 week and (f) 2 weeks post IAV infection. g, Venn diagram showing S. pneumoniae genes upregulated during SI at week 1 and week 2. h,i , Volcano plots showing differentially expressed S. pneumoniae genes during SI compared with Spn infection 24h post inoculation, (h) 1 week and (i) and 2 weeks post IAV infection. Genes commonly upregulated at both time points are highlighted in blue.

Article Snippet: S. pneumoniae (D39L) was kindly provided by Prof. Marien De Jonge and S. pneumoniae (ATCC-6303) was purchased from LGC (Germany).

Techniques: Infection, Virus, Standard Deviation

Journal: bioRxiv

Article Title: Early metabolic reprogramming licenses Streptococcus pneumoniae for Influenza-driven superinfection

doi: 10.64898/2026.01.10.698720

Figure Lengend Snippet: a , Schematic of the mouse infection model. Mice were intranasally (i.n.) primed with PBS or influenza A virus (IAV; 10 PFU) and subsequently infected with S. pneumoniae D39L at 7d post IAV infection. Bacterial inoculum was ∼1 × 10⁸ CFU for both pneumococcal infection alone (Spn) and superinfected (SI) mice. Mice were euthanized 2 h after bacterial challenge. b , Estimation of bacterial titer based on expression of the housekeeping gene gyrB, as determined by RT-qPCR. Dots indicate individual mice (n = 4-5; geometric means ± geometric s.d. are shown). Statistical significance was determined by two-tailed unpaired t -tests. c , Principal component analysis (PCA) of S. pneumoniae transcriptomes recovered from Spn and SI mice, infected as explained in (a) , from lungs harvested 2 h post infection. d , Volcano plots depicting differentially expressed S. pneumoniae genes during SI compared with Spn infection at 2 h post infection. Non-significant genes are shown in light grey, and significant genes (|L2FC| > 1, padj < 0.05) are shown in dark grey. adhE is highlighted in blue.

Article Snippet: S. pneumoniae (D39L) was kindly provided by Prof. Marien De Jonge and S. pneumoniae (ATCC-6303) was purchased from LGC (Germany).

Techniques: Infection, Virus, Expressing, Quantitative RT-PCR, Two Tailed Test

a,b Maltose (a) and mannose (b) levels in cells from bronchoalveolar lavage fluid from mock- or IAV-infected mice, measured by targeted metabolomic analysis using GC–MS. Metabolite levels are shown as relative abundance normalized to mock-infected samples and to total sample signal. Dots indicate individual mice, bars depict geometric means ± geometric s.d. (n = 4-5; one representative of at least two experiments shown). c , AdhE expression in S. pneumoniae cultured in chemically defined medium supplemented with glucose, maltose or mannose for 30 min. Dots represent individual bacterial cultures (n = 5-8, data pooled from at least two independent experiments; means ± s.d. are shown). d,e , adhE (d) and adhA (e) expression in S. pneumoniae cultured in chemically defined medium supplemented with glucose or maltose under aerobic and anaerobic conditions for 30 min. Dots represent individual bacterial cultures (n = 6, data pooled from at least two independent experiments; means ± s.d. are shown). Statistical significance was determined by unpaired two-tailed Mann–Whitney tests (a,b) , two-tailed unpaired t -tests (c) and 2-way ANOVA (d,e).

Journal: bioRxiv

Article Title: Early metabolic reprogramming licenses Streptococcus pneumoniae for Influenza-driven superinfection

doi: 10.64898/2026.01.10.698720

Figure Lengend Snippet: a,b Maltose (a) and mannose (b) levels in cells from bronchoalveolar lavage fluid from mock- or IAV-infected mice, measured by targeted metabolomic analysis using GC–MS. Metabolite levels are shown as relative abundance normalized to mock-infected samples and to total sample signal. Dots indicate individual mice, bars depict geometric means ± geometric s.d. (n = 4-5; one representative of at least two experiments shown). c , AdhE expression in S. pneumoniae cultured in chemically defined medium supplemented with glucose, maltose or mannose for 30 min. Dots represent individual bacterial cultures (n = 5-8, data pooled from at least two independent experiments; means ± s.d. are shown). d,e , adhE (d) and adhA (e) expression in S. pneumoniae cultured in chemically defined medium supplemented with glucose or maltose under aerobic and anaerobic conditions for 30 min. Dots represent individual bacterial cultures (n = 6, data pooled from at least two independent experiments; means ± s.d. are shown). Statistical significance was determined by unpaired two-tailed Mann–Whitney tests (a,b) , two-tailed unpaired t -tests (c) and 2-way ANOVA (d,e).

Article Snippet: S. pneumoniae (D39L) was kindly provided by Prof. Marien De Jonge and S. pneumoniae (ATCC-6303) was purchased from LGC (Germany).

Techniques: Infection, Metabolomic, Gas Chromatography-Mass Spectrometry, Expressing, Cell Culture, Two Tailed Test, MANN-WHITNEY

a–c , Lung bacterial burdens in mice infected for 24h with S. pneumoniae at (a) 1 week, (b) 2 weeks or (c) 4 weeks following IAV priming. Dots indicate individual mice, bars depict geometric means ± geometric standard deviation (s.d.) (n=3-4, one representative of at least two experiments shown). d, Principal component analysis (PCA) of S. pneumoniae transcriptomes recovered from Spn and SI mice 24h post infection, 1 week (dots) and 2 weeks (triangles) post IAV priming. e , Volcano plots showing differentially expressed S. pneumoniae genes during SI compared with Spn infection at week 1 (left) and week 2 (right). Non-significant genes are shown in light grey, and significant genes (|L2FC| > 1, padj < 0.05) are shown in dark grey. adhE and adhA are highlighted in blue. f,h , adhE (f) and adhA (h) expression in S. pneumoniae cultured in chemically defined medium supplemented with glucose, maltose or mannose. Dots represent individual bacterial cultures (n = 5, data pooled from at least two independent experiments; means ± s.d. are shown). i,j , adhE (i) and adhA (j) expression in S. pneumoniae cultured in chemically defined medium supplemented with glucose or maltose under aerobic or anaerobic conditions. Dots represent individual bacterial cultures (n = 4, data pooled from at least two independent experiments; means ± s.d. are shown). Statistical significance was determined by ordinary one-way ANOVA with Tukey’s multiple-comparisons test (a-c) , two-tailed unpaired t -tests (f,h) and two-way ANOVA with Fisher’s LSD test (i,j) .

Journal: bioRxiv

Article Title: Early metabolic reprogramming licenses Streptococcus pneumoniae for Influenza-driven superinfection

doi: 10.64898/2026.01.10.698720

Figure Lengend Snippet: a–c , Lung bacterial burdens in mice infected for 24h with S. pneumoniae at (a) 1 week, (b) 2 weeks or (c) 4 weeks following IAV priming. Dots indicate individual mice, bars depict geometric means ± geometric standard deviation (s.d.) (n=3-4, one representative of at least two experiments shown). d, Principal component analysis (PCA) of S. pneumoniae transcriptomes recovered from Spn and SI mice 24h post infection, 1 week (dots) and 2 weeks (triangles) post IAV priming. e , Volcano plots showing differentially expressed S. pneumoniae genes during SI compared with Spn infection at week 1 (left) and week 2 (right). Non-significant genes are shown in light grey, and significant genes (|L2FC| > 1, padj < 0.05) are shown in dark grey. adhE and adhA are highlighted in blue. f,h , adhE (f) and adhA (h) expression in S. pneumoniae cultured in chemically defined medium supplemented with glucose, maltose or mannose. Dots represent individual bacterial cultures (n = 5, data pooled from at least two independent experiments; means ± s.d. are shown). i,j , adhE (i) and adhA (j) expression in S. pneumoniae cultured in chemically defined medium supplemented with glucose or maltose under aerobic or anaerobic conditions. Dots represent individual bacterial cultures (n = 4, data pooled from at least two independent experiments; means ± s.d. are shown). Statistical significance was determined by ordinary one-way ANOVA with Tukey’s multiple-comparisons test (a-c) , two-tailed unpaired t -tests (f,h) and two-way ANOVA with Fisher’s LSD test (i,j) .

Article Snippet: S. pneumoniae (D39L) was kindly provided by Prof. Marien De Jonge and S. pneumoniae (ATCC-6303) was purchased from LGC (Germany).

Techniques: Infection, Standard Deviation, Expressing, Cell Culture, Two Tailed Test

a , Schematic of the mouse infection model. Mice were intranasally (i.n.) primed with PBS or influenza A virus (IAV; 10 PFU) and one week later infected with S. pneumoniae ATCC-6303. Bacterial inocula were ∼1 × 10⁸ CFU (D39L) or ∼1 × 10⁶ CFU (ATCC-6303) for pneumococcal infection alone (Spn) and ∼1 × 10⁴ CFU (D39L) or ∼1 × 10³ CFU (ATCC-6303) for superinfected (SI) mice. Fomepizole (10 mg kg⁻¹ in 200 ul of PBS) or PBS were administered intraperitoneally at the time of bacterial infection and again 12 h post infection. Mice were euthanized 24 h after bacterial challenge. b,c , Lung (b) and spleen (c) bacterial burdens in mice infected with S. pneumoniae D39L. d,e , Lung (d) and spleen (e) bacterial burdens in mice infected with S. pneumoniae ATCC-6303. Data are pooled from at least two independent experiments. Dots indicate individual mice (lungs n = 12-26, spleens n = 6-12), bars represent geometric means with geometric s.d. (b-e) . Statistical significance was determined by two-tailed unpaired t -tests (b-e) .

Journal: bioRxiv

Article Title: Early metabolic reprogramming licenses Streptococcus pneumoniae for Influenza-driven superinfection

doi: 10.64898/2026.01.10.698720

Figure Lengend Snippet: a , Schematic of the mouse infection model. Mice were intranasally (i.n.) primed with PBS or influenza A virus (IAV; 10 PFU) and one week later infected with S. pneumoniae ATCC-6303. Bacterial inocula were ∼1 × 10⁸ CFU (D39L) or ∼1 × 10⁶ CFU (ATCC-6303) for pneumococcal infection alone (Spn) and ∼1 × 10⁴ CFU (D39L) or ∼1 × 10³ CFU (ATCC-6303) for superinfected (SI) mice. Fomepizole (10 mg kg⁻¹ in 200 ul of PBS) or PBS were administered intraperitoneally at the time of bacterial infection and again 12 h post infection. Mice were euthanized 24 h after bacterial challenge. b,c , Lung (b) and spleen (c) bacterial burdens in mice infected with S. pneumoniae D39L. d,e , Lung (d) and spleen (e) bacterial burdens in mice infected with S. pneumoniae ATCC-6303. Data are pooled from at least two independent experiments. Dots indicate individual mice (lungs n = 12-26, spleens n = 6-12), bars represent geometric means with geometric s.d. (b-e) . Statistical significance was determined by two-tailed unpaired t -tests (b-e) .

Article Snippet: S. pneumoniae (D39L) was kindly provided by Prof. Marien De Jonge and S. pneumoniae (ATCC-6303) was purchased from LGC (Germany).

Techniques: Infection, Virus, Two Tailed Test

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